I'm sure there has been much more advanced study/calc's done on this, would be good to find and have a read. But i'm sure for the majority pretty much what @Gripless said above, bends are bads, pipe sizes should be in between the turbo outlet and the TB inlet size.
Mines not quite what you're describing, but the hot side does have about 450 degrees of bends in it. After having reading through this and getting my head around it, I think i'll have another attempt.