Not sure what the main engine fuse runs further down, but grab a wiring diagram and look at the next level of fuses downstream.
have you upgraded any electrical component that run off those i.e. fuel pump, coils, injectors, Ecu etc.
guess at the least the voltage has been checked and are ok from alternator? Won't always show on digital multimeter but good start.
when you replaced the fuse did you just get the same value or check the manual and confirm cover to make sure it was the correct one to start with? Could be lucky and just have a fuse that's to small.
is the rest of your loom tidy? No shorts from unterminated or poorly joined cables.
other free things to consider is anything electrical cable or component running closer to heat sources as the more you heat them the less efficient they run, which can increase current draw.
Disclaimer: I know nothing about anything, ever.